Chemicals and Drugs

Epidermal Growth Factor

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

8 entry terms
  • EGF
  • Epidermal Growth Factor-Urogastrone
  • Human Urinary Gastric Inhibitor
  • Urogastrone
  • beta-Urogastrone
  • Growth Factor, Epidermal
  • Growth Factor-Urogastrone, Epidermal
  • beta Urogastrone

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2000(1982); use PEPTIDES 1977-1981; for UROGASTRONE use GASTROINTESTINAL HORMONES 1963-1981

MeSH Record

Previous Indexing

  • Gastrointestinal Hormones (1966-1974)
  • Growth Substances (1966-1976)
  • Peptides (1966-1976)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.317w.350w
  2. D12.644w.276.382.500w
  3. D12.776w.467.382.500w
  4. D23.529.382.500w

MeSH Record

NLM Classification

WK 170

AMA Style

References

  1. National Library of Medicine. Epidermal Growth Factor. Medical Subject Headings (MeSH). 2026. Unique ID D004815. http://id.nlm.nih.gov/mesh/2026/D004815
  2. Epidermal Growth Factor. In: Wikipedia. https://en.wikipedia.org/wiki/Epidermal_growth_factor
  3. Epidermal Growth Factor. In: Wikidata. https://www.wikidata.org/wiki/Q424374