Chemicals and Drugs

Enterotoxin Receptors

Guanylate cyclase-coupled receptors that bind bacterial ENTEROTOXINS, as well as the endogenous peptides guanylin and uroguanylin. Ligand binding stimulates production of CYCLIC GMP by EPITHELIAL CELLS of the intestinal lumen, altering barrier permeability and mucus secretion. Mutations in the gene (GUCY2C) encoding this receptor are associated with some cases of hereditary diarrhea (Diarrhea 6) and MECONIUM ILEUS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Guanylate cyclase-coupled receptors that bind bacterial ENTEROTOXINS, as well as the endogenous peptides guanylin and uroguanylin. Ligand binding stimulates production of CYCLIC GMP by EPITHELIAL CELLS of the intestinal lumen, altering barrier permeability and mucus secretion. Mutations in the gene (GUCY2C) encoding this receptor are associated with some cases of hereditary diarrhea (Diarrhea 6) and MECONIUM ILEUS.

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Classification

Broader headings

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See Also

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Synonyms

40 entry terms
  • Enterotoxin Receptor
  • Enterotoxin-Guanylin Receptor
  • Enterotoxin-Guanylin Receptors
  • GC-C Receptor
  • GC-C Receptors
  • Guanyl Cyclase-C Receptor
  • Guanyl Cyclase-C Receptors
  • Guanylin-Uroguanylin Receptor
  • Guanylin-Uroguanylin Receptors
  • Guanylyl Cyclase C
  • Heat-Stable Enterotoxin Receptor
  • Heat-Stable Enterotoxin Receptors
  • Receptor, Enterotoxin
  • Receptor, Guanyl Cyclase-C
  • Receptors, Enterotoxin
  • Receptors, Guanyl Cyclase-C
  • Cyclase C, Guanylyl
  • Cyclase-C Receptors, Guanyl
  • Enterotoxin Guanylin Receptor
  • Enterotoxin Guanylin Receptors
  • Enterotoxin Receptor, Heat-Stable
  • Enterotoxin Receptors, Heat-Stable
  • GC C Receptor
  • GC C Receptors
  • Guanyl Cyclase C Receptor
  • Guanyl Cyclase C Receptors
  • Guanylin Uroguanylin Receptor
  • Guanylin Uroguanylin Receptors
  • Heat Stable Enterotoxin Receptor
  • Heat Stable Enterotoxin Receptors
  • Receptor, Enterotoxin-Guanylin
  • Receptor, GC-C
  • Receptor, Guanyl Cyclase C
  • Receptor, Guanylin-Uroguanylin
  • Receptor, Heat-Stable Enterotoxin
  • Receptors, Enterotoxin-Guanylin
  • Receptors, GC-C
  • Receptors, Guanyl Cyclase C
  • Receptors, Guanylin-Uroguanylin
  • Receptors, Heat-Stable Enterotoxin

MeSH Record

Aspects Covered

18 allowable subheadings

Indexed with the subheadings administration & dosage, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2018 (1981)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.520w.650.600w.500w.250
  2. D12.776w.543w.750w.700w.250
  3. D12.776w.543w.750w.750w.330

AMA Style

References

  1. National Library of Medicine. Enterotoxin Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D000074261. http://id.nlm.nih.gov/mesh/2026/D000074261
  2. Enterotoxin Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q113232891