Chemicals and Drugs

Enprostil

A synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has been shown to be efficient and safe in the treatment of gastroduodenal ulcers.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has been shown to be efficient and safe in the treatment of gastroduodenal ulcers.

Chemical Identity

Chemical Information

Molecular Formula
C23H28O6
Molecular Weight
400.5 g/mol
CAS Registry No.
73121-56-9
IUPAC Name
methyl 7-[(1S,2S,3S)-3-hydroxy-2-[(E,3S)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate
InChIKey
PTOJVMZPWPAXER-FPXSIRDUSA-N
SMILES
COC(=O)CCC=C=CC[C@H]1[C@@H]([C@H](CC1=O)O)/C=C/[C@@H](COC2=CC=CC=C2)O
MeSH Unique ID
D016620
Source
PubChem CID 9978336

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

13 entry terms
  • Enprostil, (1R-(1(R*),2beta(1E,3R*),3alpha))-Isomer
  • Enprostil, (1R-(1alpha(S*),2beta(1E,3R*),3alpha))-Isomer
  • Enprostil, (1R-(1alpha,2beta(1E,3R*),3alpha))-Isomer
  • Enprostil, (1S-(1alpha(R*),2beta(1E,3R*),3alpha))-Isomer
  • Enprostil, (1S-(1alpha(S*),2beta(1E,3R*),3alpha))-Isomer
  • Enprostil, (1alpha(R*),2beta(1E,3R*),3alpha)-(+-)-Isomer
  • Enprostil, (1alpha(R*),2beta(1E,3S*),3alpha)-(+-)-Isomer
  • Enprostil, (1alpha,2alpha(1E,3S*),3beta)-(+-)-Isomer
  • Enprostil, (1alpha,2beta(1E,3R*),3alpha)-(+-)-Isomer
  • Gardrin
  • RS-84135
  • RS 84135
  • RS84135

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92; was ENPROSTIL (NM) 1985-91

MeSH Record

Previous Indexing

  • Prostaglandins E, Synthetic (1978-1991)

MeSH Hierarchy

Tree Numbers

  1. D10w.251w.355w.255w.550w.775.450.350w
  2. D23.469.050w.175w.725w.775.450.350w
  3. D23.469.700.660.250w

AMA Style

References

  1. National Library of Medicine. Enprostil. Medical Subject Headings (MeSH). 2026. Unique ID D016620. http://id.nlm.nih.gov/mesh/2026/D016620
  2. Enprostil. In: Wikipedia. https://en.wikipedia.org/wiki/Enprostil
  3. Enprostil. In: Wikidata. https://www.wikidata.org/wiki/Q5379483
  4. Enprostil. In: PubChem Compound. CID 9978336. https://pubchem.ncbi.nlm.nih.gov/compound/9978336