Chemicals and Drugs

Enalaprilat

The active metabolite of ENALAPRIL and one of the potent, intravenously administered, ANGIOTENSIN-CONVERTING ENZYME INHIBITORS. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The active metabolite of ENALAPRIL and one of the potent, intravenously administered, ANGIOTENSIN-CONVERTING ENZYME INHIBITORS. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion.

Chemical Identity

Chemical Information

Molecular Formula
C18H28N2O7
Molecular Weight
384.4 g/mol
CAS Registry No.
84680-54-6
IUPAC Name
(2S)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid;dihydrate
InChIKey
MZYVOFLIPYDBGD-MLZQUWKJSA-N
SMILES
C[C@@H](C(=O)N1CCC[C@H]1C(=O)O)N[C@@H](CCC2=CC=CC=C2)C(=O)O.O.O
MeSH Unique ID
D015773
Source
PubChem CID 6917719

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • 1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate
  • Enalaprilat Anhydrous
  • Enalaprilat Citrate, Anhydrous
  • Enalaprilat Dihydrate
  • Enalaprilat, (R)-Isomer, Anhydrous
  • Enalaprilic Acid
  • MK-422
  • Pres iv
  • Vasotec
  • Xanef
  • MK 422
  • MK422

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1990

MeSH Record

Previous Indexing

  • Dipeptides (1966-1985)
  • Enalapril (1986-1989)

MeSH Hierarchy

Tree Number

  1. D12.644w.456w.345w.360w.300

AMA Style

References

  1. National Library of Medicine. Enalaprilat. Medical Subject Headings (MeSH). 2026. Unique ID D015773. http://id.nlm.nih.gov/mesh/2026/D015773
  2. Enalaprilat. In: Wikidata. https://www.wikidata.org/wiki/Q27126932
  3. Enalaprilat. In: PubChem Compound. CID 6917719. https://pubchem.ncbi.nlm.nih.gov/compound/6917719