Structured Summary
Abstract
A heterotrimeric protein complex composed of 110 kDa elongin A, 18 kDa elongin B, and 15 kDa elongin C subunits. It functions as a positive regulator of RNA POLYMERASE II, increasing its rate of transcriptional elongation by suppressing transient pausing along the DNA template. Elongin A is the transcriptionally active component; elongins B and C enhance its activity.
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Broader headings
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Synonyms
13 entry terms
- Elongin Complex
- SIII Elongation Factor
- TF-SIII
- Transcription Factor SIII
- Complex, Elongin
- Elongation Factor, SIII
- SIII, Transcription Factor
- EloA Protein
- EloB Protein
- EloC Protein
- Elongin A
- Elongin B
- Elongin C
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018 (1995)
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AMA Style
References
- National Library of Medicine. Elongin. Medical Subject Headings (MeSH). 2026. Unique ID D000075065. http://id.nlm.nih.gov/mesh/2026/D000075065
- Elongin. In: Wikidata. https://www.wikidata.org/wiki/Q21114386