Chemicals and Drugs

Elongation Factor 2 Kinase

A monomeric calcium-calmodulin-dependent protein kinase subtype that specifically phosphorylates PEPTIDE ELONGATION FACTOR 2. The enzyme lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE, however it is regulated by phosphorylation by PROTEIN KINASE A and through intramolecular autophosphorylation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A monomeric calcium-calmodulin-dependent protein kinase subtype that specifically phosphorylates PEPTIDE ELONGATION FACTOR 2. The enzyme lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE, however it is regulated by phosphorylation by PROTEIN KINASE A and through intramolecular autophosphorylation.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

17 entry terms
  • CAM Kinase III
  • Calcium-Calmodulin-Dependent Protein Kinase Type 3
  • Calmodulin-Dependent Protein Kinase III
  • Cam PK III
  • E-2 Kinase
  • EF-2 Kinase
  • Eukaryotic Elongation Factor-2 Kinase
  • Protein Kinase CPK3
  • eEF-2-Specific Ca and Calmodulin-Dependent Protein Kinase III
  • Calcium Calmodulin Dependent Protein Kinase Type 3
  • Calmodulin Dependent Protein Kinase III
  • E 2 Kinase
  • EF 2 Kinase
  • Eukaryotic Elongation Factor 2 Kinase
  • Kinase CPK3, Protein
  • Kinase, EF-2
  • eEF 2 Specific Ca and Calmodulin Dependent Protein Kinase III

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008(1987)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.125w.425w
  2. D12.776w.476.563w.125w.425w

AMA Style

References

  1. National Library of Medicine. Elongation Factor 2 Kinase. Medical Subject Headings (MeSH). 2026. Unique ID D054736. http://id.nlm.nih.gov/mesh/2026/D054736
  2. Elongation Factor 2 Kinase. In: Wikipedia. https://en.wikipedia.org/wiki/Elongation_factor_2_kinase
  3. Elongation Factor 2 Kinase. In: Wikidata. https://www.wikidata.org/wiki/Q5367166