Chemicals and Drugs

Electron Transport Complex I

A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.

MeSH Record

Classification

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MeSH Record

Synonyms

22 entry terms
  • Respiratory Complex I
  • Complex I Dehydrogenase
  • NADH DH I
  • NADH Dehydrogenase (Ubiquinone)
  • NADH Dehydrogenase Complex 1
  • NADH Dehydrogenase I
  • NADH Q1 Oxidoreductase
  • NADH-CoQ Reductase
  • NADH-Coenzyme Q Reductase
  • NADH-Ubiquinone Oxidoreductase
  • NADH-Ubiquinone Reductase
  • Rotenone-Sensitive Mitochondrial NADH-Ubiquinone Oxidoreductase
  • Ubiquinone Reductase
  • Dehydrogenase, Complex I
  • NADH CoQ Reductase
  • NADH Coenzyme Q Reductase
  • NADH Ubiquinone Oxidoreductase
  • NADH Ubiquinone Reductase
  • Oxidoreductase, NADH Q1
  • Oxidoreductase, NADH-Ubiquinone
  • Reductase, NADH-Ubiquinone
  • Rotenone Sensitive Mitochondrial NADH Ubiquinone Oxidoreductase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; for NADH DEHYDROGENASE (UBIQUINONE) use ELECTRON TRANSPORT COMPLEX I (NM) 1992-2003; for NADH DEHYDROGENASE COMPLEX 1 use NADH DEHYDROGENASE 1989-2003; for UBIQUINONE REDUCTASE use NAD(P)H DEHYDROGENASE (QUINONE) 1992-1999

MeSH Record

Previous Indexing

  • Cytochrome Reductases (1983-2003)
  • NADH, NADPH Oxidoreductases (1992-2003)

MeSH Hierarchy

Tree Numbers

  1. D05.500w.562w.249w
  2. D08.811w.600w.250.500w.500w
  3. D08.811w.682w.608.504w
  4. D12.776w.157w.427w.374w.375w.863w
  5. D12.776w.157w.530w.450w.250.875w.300w
  6. D12.776w.331w.199w.500w
  7. D12.776w.543w.277.500w.500w
  8. D12.776w.543w.585w.450w.250.875w.437w
  9. D12.776w.556w.579w.374w.375w.140w

AMA Style

References

  1. National Library of Medicine. Electron Transport Complex I. Medical Subject Headings (MeSH). 2026. Unique ID D042967. http://id.nlm.nih.gov/mesh/2026/D042967
  2. Electron Transport Complex I. In: Wikipedia. https://en.wikipedia.org/wiki/Respiratory_complex_I
  3. Electron Transport Complex I. In: Wikidata. https://www.wikidata.org/wiki/Q22326958