Chemicals and Drugs

Eflornithine

An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.

Chemical Identity

Chemical Information

Molecular Formula
C6H12F2N2O2
Molecular Weight
182.17 g/mol
CAS Registry No.
70052-12-9
IUPAC Name
2,5-diamino-2-(difluoromethyl)pentanoic acid
InChIKey
VLCYCQAOQCDTCN-UHFFFAOYSA-N
SMILES
C(CC(C(F)F)(C(=O)O)N)CN
MeSH Unique ID
D000518
Source
PubChem CID 3009

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

16 entry terms
  • DL-alpha-Difluoromethylornithine
  • Difluoromethylornithine
  • alpha-Difluoromethyl Ornithine
  • alpha-Difluoromethylornithine
  • DL alpha Difluoromethylornithine
  • Ornithine, alpha-Difluoromethyl
  • alpha Difluoromethyl Ornithine
  • alpha Difluoromethylornithine
  • Eflornithine Hydrochloride
  • Eflornithine Monohydrochloride, Monohydrate
  • MDL-71,782 A
  • Ornidyl
  • RMI 71782
  • Vaniqa
  • MDL 71,782 A
  • MDL71,782 A

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1991; use ALPHA-DIFLUOROMETHYLORNITHINE 1987-1990

MeSH Record

Previous Indexing

  • Ornithine (1966-1974)
  • Ornithine/analogs & derivatives (1975-1986)

MeSH Hierarchy

Tree Numbers

  1. D12.125w.068.665w.340w
  2. D12.125w.095w.765w.340w

AMA Style

References

  1. National Library of Medicine. Eflornithine. Medical Subject Headings (MeSH). 2026. Unique ID D000518. http://id.nlm.nih.gov/mesh/2026/D000518
  2. Eflornithine. In: Wikipedia. https://en.wikipedia.org/wiki/Eflornithine
  3. Eflornithine. In: Wikidata. https://www.wikidata.org/wiki/Q424751
  4. Eflornithine. In: PubChem Compound. CID 3009. https://pubchem.ncbi.nlm.nih.gov/compound/3009