Chemicals and Drugs

Ectodysplasins

Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.

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Synonyms

7 entry terms
  • Ectodysplasin
  • Ectodysplasin-A
  • Ectodysplasin A
  • Ectodysplasin A, Isoform 1
  • Ectodysplasin A, Isoform 2
  • Ectodysplasin A1
  • Ectodysplasin A2

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007(1999)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.275
  2. D12.644w.276.374w.750w.186
  3. D12.776w.395w.550w.275
  4. D12.776w.467.374w.750w.186
  5. D12.776w.543w.550w.275
  6. D23.529.374w.750w.186

AMA Style

References

  1. National Library of Medicine. Ectodysplasins. Medical Subject Headings (MeSH). 2026. Unique ID D053331. http://id.nlm.nih.gov/mesh/2026/D053331
  2. Ectodysplasins. In: Wikidata. https://www.wikidata.org/wiki/Q76715386