Structured Summary
Abstract
A 5-ALPHA-REDUCTASE INHIBITOR that is reported to inhibit both type-1 and type2 isoforms of the enzyme and is used to treat BENIGN PROSTATIC HYPERPLASIA.
Chemical Identity
Chemical Information
- Molecular Formula
- C27H30F6N2O2
- Molecular Weight
- 528.5 g/mol
- CAS Registry No.
- 164656-23-9
- IUPAC Name
- (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
- InChIKey
- JWJOTENAMICLJG-QWBYCMEYSA-N
- SMILES
- C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C
- MeSH Unique ID
- D000068538
- Source
- PubChem CID 6918296
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
7 entry terms
- 17beta-N-(2,5-bis(trifluoromethyl))phenyl-carbamoyl-4-aza-5alpha-androst-1-en-3-one
- Avodart
- GG 745
- GG-745
- GG745
- GI198745
- 745, GG
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2016 (1998)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Dutasteride. Medical Subject Headings (MeSH). 2026. Unique ID D000068538. http://id.nlm.nih.gov/mesh/2026/D000068538
- Dutasteride. In: Wikipedia. https://en.wikipedia.org/wiki/Dutasteride
- Dutasteride. In: Wikidata. https://www.wikidata.org/wiki/Q424760
- Dutasteride. In: PubChem Compound. CID 6918296. https://pubchem.ncbi.nlm.nih.gov/compound/6918296