Chemicals and Drugs

Duocarmycins

A group of pyrroloindole compounds often with additional spirocyclic unit(s) and their analogs originally isolated from STREPTOMYCES. They bind DNA minor grooves with adenine-N3 alkylation activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A group of pyrroloindole compounds often with additional spirocyclic unit(s) and their analogs originally isolated from STREPTOMYCES. They bind DNA minor grooves with adenine-N3 alkylation activity.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

1 entry terms
  • Duocarmycin

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2020

MeSH Record

Previous Indexing

  • Indoles (1988-2019)
  • Pyrroles (1988-2019)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.129w.578.275w
  2. D03w.633.100.473.278w

AMA Style

References

  1. National Library of Medicine. Duocarmycins. Medical Subject Headings (MeSH). 2026. Unique ID D000080890. http://id.nlm.nih.gov/mesh/2026/D000080890
  2. Duocarmycins. In: Wikipedia. https://en.wikipedia.org/wiki/Duocarmycin
  3. Duocarmycins. In: Wikidata. https://www.wikidata.org/wiki/Q5315852