Chemicals and Drugs

Donepezil

An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.

Chemical Identity

Chemical Information

Molecular Formula
C24H29NO3
Molecular Weight
379.5 g/mol
CAS Registry No.
120014-06-4
IUPAC Name
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
InChIKey
ADEBPBSSDYVVLD-UHFFFAOYSA-N
SMILES
COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
MeSH Unique ID
D000077265
Source
PubChem CID 3152

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride
  • Aricept
  • Donepezil Hydrochloride
  • Donepezilium Oxalate Trihydrate
  • E 2020
  • E-2020
  • E2020
  • Eranz

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1992)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.847w.486.487.280w
  2. D03w.383.621.238w
  3. D04w.615w.486.487.280w

AMA Style

References

  1. National Library of Medicine. Donepezil. Medical Subject Headings (MeSH). 2026. Unique ID D000077265. http://id.nlm.nih.gov/mesh/2026/D000077265
  2. Donepezil. In: Wikipedia. https://en.wikipedia.org/wiki/Donepezil
  3. Donepezil. In: Wikidata. https://www.wikidata.org/wiki/Q415081
  4. Donepezil. In: PubChem Compound. CID 3152. https://pubchem.ncbi.nlm.nih.gov/compound/3152