Chemicals and Drugs

Dolutegravir

An HIV integrase inhibitor that is used in the treatment of HIV INFECTIONS in combination with other ANTI-HIV AGENTS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An HIV integrase inhibitor that is used in the treatment of HIV INFECTIONS in combination with other ANTI-HIV AGENTS.

Chemical Identity

Chemical Information

Molecular Formula
C20H19F2N3O5
Molecular Weight
419.4 g/mol
CAS Registry No.
1051375-16-6
IUPAC Name
(3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide
InChIKey
RHWKPHLQXYSBKR-BMIGLBTASA-N
SMILES
C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
MeSH Unique ID
D000099226
Source
PubChem CID 54726191

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • (4R,12aS)-N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-Pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide
  • (4R,9aS)-5-hydroxy-4-methyl-6,10-dioxo-3,4,6,9,9a,10-hexahydro-2H-1-oxa-4a,8a-diaza-anthracene-7-carboxylic acid- 2,4 difluorobenzylamide
  • (4S,12aR)-N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide
  • (4S,12aS)-N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide
  • Dolutegravir S,R Isomer
  • Dolutegravir S,S-Isomer
  • Dolutegravir Sodium
  • Dolutegravir Sodium Monohydrate
  • GSK 1349572A
  • GSK-1349572
  • GSK-1349572A
  • GSK1349572A
  • S-GSK1349572
  • Tivicay
  • Tivicay PD

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2026 (2011)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.533.312w
  2. D03w.383.606w.394w
  3. D03w.383.725w.791.397w
  4. D03w.633.300.445w

AMA Style

References

  1. National Library of Medicine. Dolutegravir. Medical Subject Headings (MeSH). 2026. Unique ID D000099226. http://id.nlm.nih.gov/mesh/2026/D000099226
  2. Dolutegravir. In: Wikipedia. https://en.wikipedia.org/wiki/Dolutegravir
  3. Dolutegravir. In: Wikidata. https://www.wikidata.org/wiki/Q937224
  4. Dolutegravir. In: PubChem Compound. CID 54726191. https://pubchem.ncbi.nlm.nih.gov/compound/54726191