Chemicals and Drugs

Disopyramide

A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.

Chemical Identity

Chemical Information

Molecular Formula
C21H29N3O
Molecular Weight
339.5 g/mol
CAS Registry No.
3737-09-5
IUPAC Name
4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide
InChIKey
UVTNFZQICZKOEM-UHFFFAOYSA-N
SMILES
CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C
MeSH Unique ID
D004206
Source
PubChem CID 3114

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

24 entry terms
  • Diisopyramide
  • Disopyramide Monohydrochloride
  • Disopyramide Phosphate
  • Disopyramide Phosphate (1:1)
  • Disopyramide Phosphate (1:1), (+-)-Isomer
  • Disopyramide Phosphate (1:1), (R)-Isomer
  • Disopyramide Phosphate (1:1), (S)-Isomer
  • Disopyramide, (+-)-Isomer
  • Disopyramide, (R)-Isomer
  • Disopyramide, (S)-Isomer
  • Disopyramide, D-Tartrate (1:1), (S)-Isomer
  • Disopyramide, L-Tartrate (1:1), (R)-Isomer
  • Disopyramide, L-Tartrate (1:1), (S)-Isomer
  • Disopyramide, L-Tartrate (1:2), (+-)-Isomer
  • Disopyramide, L-Tartrate, (S)-isomer
  • Norpace
  • Palpitin
  • Palpitine
  • Rhythmodan
  • Ritmilen
  • Rythmilen
  • SC-13957
  • SC 13957
  • SC13957

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

84(72); was see under PYRIDINES 1972-83 (Prov 1972-74)

MeSH Record

Previous Indexing

  • Anti-Arrhythmia Agents (1966-1971)
  • Pyridines (1966-1971)

MeSH Hierarchy

Tree Number

  1. D03w.383.725w.227w

MeSH Record

NLM Classification

QV 150

AMA Style

References

  1. National Library of Medicine. Disopyramide. Medical Subject Headings (MeSH). 2026. Unique ID D004206. http://id.nlm.nih.gov/mesh/2026/D004206
  2. Disopyramide. In: Wikipedia. https://en.wikipedia.org/wiki/Disopyramide
  3. Disopyramide. In: Wikidata. https://www.wikidata.org/wiki/Q425120
  4. Disopyramide. In: PubChem Compound. CID 3114. https://pubchem.ncbi.nlm.nih.gov/compound/3114