Chemicals and Drugs

Disks Large Homolog 4 Protein

A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

10 entry terms
  • Discs Large Homolog 4 Protein
  • PSD-95 Protein
  • PSD95 Protein
  • Postsynaptic Density Protein 95
  • SAP-90 Protein
  • SAP90 Protein
  • Synapse-Associated Protein 90
  • PSD 95 Protein
  • SAP 90 Protein
  • Synapse Associated Protein 90

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Intracellular Signaling Peptides and Proteins (2005-2017)
  • Membrane Proteins (2005-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.650.450w.750w
  2. D12.644w.360.265w
  3. D12.776w.476.265w
  4. D12.776w.543w.219w
  5. D12.776w.631w.224w

AMA Style

References

  1. National Library of Medicine. Disks Large Homolog 4 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000076122. http://id.nlm.nih.gov/mesh/2026/D000076122
  2. Disks Large Homolog 4 Protein. In: Wikipedia. https://en.wikipedia.org/wiki/DLG4
  3. Disks Large Homolog 4 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21102524