Chemicals and Drugs

Diphtheria Toxin

An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

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See Also

MeSH Record

Synonyms

2 entry terms
  • Corynebacterium Diphtheriae Toxin
  • Toxin, Corynebacterium Diphtheriae

MeSH Record

Aspects Covered

27 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

/antag permitted but consider also DIPHTHERIA ANTITOXIN

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.400w.725w.115.220w
  2. D23.946w.123.305w

MeSH Record

NLM Classification

WC 320

AMA Style

References

  1. National Library of Medicine. Diphtheria Toxin. Medical Subject Headings (MeSH). 2026. Unique ID D004167. http://id.nlm.nih.gov/mesh/2026/D004167
  2. Diphtheria Toxin. In: Wikipedia. https://en.wikipedia.org/wiki/Diphtheria_toxin
  3. Diphtheria Toxin. In: Wikidata. https://www.wikidata.org/wiki/Q421580