Chemicals and Drugs

Diphenoxylate

A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.

Chemical Identity

Chemical Information

Molecular Formula
C30H32N2O2
Molecular Weight
452.6 g/mol
CAS Registry No.
915-30-0
IUPAC Name
ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate
InChIKey
HYPPXZBJBPSRLK-UHFFFAOYSA-N
SMILES
CCOC(=O)C1(CCN(CC1)CCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4
MeSH Unique ID
D004157
Source
PubChem CID 13505

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • Diphenoxylate Hydrochloride
  • Diphenoxylate Monohydrochloride
  • Hydrochloride, Diphenoxylate
  • Monohydrochloride, Diphenoxylate

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under ISONIPECOTIC ACIDS 1975-90

MeSH Record

Previous Indexing

  • Isonipecotic Acids (1970-1974)
  • Nitriles (1974)

MeSH Hierarchy

Tree Numbers

  1. D03w.066.399.300w
  2. D03w.383.621.349.300w

AMA Style

References

  1. National Library of Medicine. Diphenoxylate. Medical Subject Headings (MeSH). 2026. Unique ID D004157. http://id.nlm.nih.gov/mesh/2026/D004157
  2. Diphenoxylate. In: Wikipedia. https://en.wikipedia.org/wiki/Diphenoxylate
  3. Diphenoxylate. In: Wikidata. https://www.wikidata.org/wiki/Q416431
  4. Diphenoxylate. In: PubChem Compound. CID 13505. https://pubchem.ncbi.nlm.nih.gov/compound/13505