Chemicals and Drugs

Dinoprostone

The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.

Chemical Identity

Chemical Information

Molecular Formula
C20H32O5
Molecular Weight
352.5 g/mol
CAS Registry No.
363-24-6
IUPAC Name
(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
InChIKey
XEYBRNLFEZDVAW-ARSRFYASSA-N
SMILES
CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)O
MeSH Unique ID
D015232
Source
PubChem CID 5280360

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

14 entry terms
  • PGE2
  • PGE2 alpha
  • PGE2alpha
  • Prostaglandin E2
  • Prostaglandin E2 alpha
  • Prostaglandin E2alpha
  • E2 alpha, Prostaglandin
  • E2, Prostaglandin
  • E2alpha, Prostaglandin
  • alpha, PGE2
  • alpha, Prostaglandin E2
  • Prepidil Gel
  • Prostenon
  • Gel, Prepidil

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

do not confuse with DINOPROST; /biosyn /physiol permitted

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • Prostaglandins (1966-1974)
  • Prostaglandins E (1975-1988)

MeSH Hierarchy

Tree Numbers

  1. D10w.251w.355w.255w.550w.250w.200w
  2. D23.469.050w.175w.725w.250w.200w

AMA Style

References

  1. National Library of Medicine. Dinoprostone. Medical Subject Headings (MeSH). 2026. Unique ID D015232. http://id.nlm.nih.gov/mesh/2026/D015232
  2. Dinoprostone. In: Wikipedia. https://en.wikipedia.org/wiki/Prostaglandin_E2
  3. Dinoprostone. In: Wikidata. https://www.wikidata.org/wiki/Q416554
  4. Dinoprostone. In: PubChem Compound. CID 5280360. https://pubchem.ncbi.nlm.nih.gov/compound/5280360