Chemicals and Drugs

Dihydrouracil Dehydrogenase (NAD+)

An enzyme that catalyzes the oxidation of 5,6-dihydrouracil to URACIL using NAD as a cofactor. This enzyme also plays a role in the catabolism of the antimetabolite 5-FLUOROURACIL.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that catalyzes the oxidation of 5,6-dihydrouracil to URACIL using NAD as a cofactor. This enzyme also plays a role in the catabolism of the antimetabolite 5-FLUOROURACIL.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • Dihydrothymine Dehydrogenase (NAD)
  • Dihydrouracil Dehydrogenase
  • Dihydrouracil Dehydrogenase (NAD)
  • Dehydrogenase, Dihydrouracil

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1970)

MeSH Record

Previous Indexing

  • Oxidoreductases (1983-2003)
  • Oxidoreductases Acting on CH-CH Group Donors (2004-2005)

MeSH Hierarchy

Tree Number

  1. D08.811w.682w.660.325

AMA Style

References

  1. National Library of Medicine. Dihydrouracil Dehydrogenase (NAD+). Medical Subject Headings (MeSH). 2026. Unique ID D050744. http://id.nlm.nih.gov/mesh/2026/D050744
  2. Dihydrouracil Dehydrogenase (NAD+). In: Wikidata. https://www.wikidata.org/wiki/Q76130229