Chemicals and Drugs

Dihydroergotoxine

A mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES.

Chemical Identity

Chemical Information

Molecular Formula
C34H41N5O8S
Molecular Weight
679.8 g/mol
CAS Registry No.
11032-41-0
IUPAC Name
(6aR,9R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;methanesulfonic acid
InChIKey
ADYPXRFPBQGGAH-WVVAGBSPSA-N
SMILES
C[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)CC4=CC=CC=C4)NC(=O)[C@@H]5CC6[C@@H](CC7=CNC8=CC=CC6=C78)N(C5)C.CS(=O)(=O)O
MeSH Unique ID
D004088
Source
PubChem CID 6420006

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

5 entry terms
  • Co-Dergocrine
  • Dihydroergotoxin
  • Ergot Alkaloids, Hydrogenated
  • Alkaloids, Hydrogenated Ergot
  • Hydrogenated Ergot Alkaloids

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1977(1975); for ERGOT ALKALOIDS, HYDROGENATED use ERGOLOID MESYLATES 1992-2001

MeSH Record

Previous Indexing

  • Ergot Mesylates (1973-1974)

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.327.412.250
  2. D03w.633.400.562.400

AMA Style

References

  1. National Library of Medicine. Dihydroergotoxine. Medical Subject Headings (MeSH). 2026. Unique ID D004088. http://id.nlm.nih.gov/mesh/2026/D004088
  2. Dihydroergotoxine. In: Wikidata. https://www.wikidata.org/wiki/Q16633838
  3. Dihydroergotoxine. In: PubChem Compound. CID 6420006. https://pubchem.ncbi.nlm.nih.gov/compound/6420006