Chemicals and Drugs

Dihematoporphyrin Ether

The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States.

Chemical Identity

Chemical Information

Molecular Formula
C68H106N8O11
Molecular Weight
1211.6 g/mol
IUPAC Name
3-[12-[1-[1-[13,17-bis(2-carboxyethyl)-7-(1-hydroxyethyl)-3,8,12,18-tetramethyl-1,4,5,6,7,8,9,10,11,14,15,16,19,20,21,22,23,24-octadecahydroporphyrin-2-yl]ethoxy]ethyl]-18-(2-carboxyethyl)-7-(1-hydroxyethyl)-3,8,13,17-tetramethyl-1,2,3,4,5,6,9,10,11,14,15,16,19,20,21,22,23,24-octadecahydroporphyrin-2-yl]propanoic acid
InChIKey
WVZIWHPFLJPBPL-UHFFFAOYSA-N
SMILES
CC1C2CC3C(=C(C(N3)CC4C(=C(C(N4)CC5C(=C(C(N5)CC(C1CCC(=O)O)N2)CCC(=O)O)C)C)C(C)OC(C)C6=C(C7CC8C(C(C(N8)CC9C(=C(C(N9)CC1C(=C(C(N1)CC6N7)C)CCC(=O)O)CCC(=O)O)C)C)C(C)O)C)C)C(C)O
MeSH Unique ID
D017323
Source
PubChem CID 139032869

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

7 entry terms
  • DHP Ether
  • Dihematoporphyrin Ester
  • Porfimer
  • Ether, Dihematoporphyrin
  • Photofrin
  • Photofrin II
  • Porfimer Sodium

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was DIHEMATOPORPHYRIN ETHER (NM) 1985-92

MeSH Record

Previous Indexing

  • Hematoporphyrins (1985-1992)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.129w.578.840w.500w.462.400.200
  2. D03w.633.400.909w.500w.462.400.200
  3. D04w.345w.783w.500w.462.400.200
  4. D23.767w.727w.462.400.200

AMA Style

References

  1. National Library of Medicine. Dihematoporphyrin Ether. Medical Subject Headings (MeSH). 2026. Unique ID D017323. http://id.nlm.nih.gov/mesh/2026/D017323
  2. Dihematoporphyrin Ether. In: Wikidata. https://www.wikidata.org/wiki/Q27263441
  3. Dihematoporphyrin Ether. In: PubChem Compound. CID 139032869. https://pubchem.ncbi.nlm.nih.gov/compound/139032869