Chemicals and Drugs

Dextropropoxyphene

A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.

Chemical Identity

Chemical Information

Molecular Formula
C22H29NO2
Molecular Weight
339.5 g/mol
CAS Registry No.
469-62-5
IUPAC Name
[(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate
InChIKey
XLMALTXPSGQGBX-GCJKJVERSA-N
SMILES
CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C
MeSH Unique ID
D011431
Source
PubChem CID 10100

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

13 entry terms
  • D-Propoxyphene
  • Propoxyphene
  • D Propoxyphene
  • Darvon
  • Propoxyphene Hydrochloride
  • Propoxyphene Hydrochloride, (R*,R*)-(+-)-Isomer
  • Propoxyphene Hydrochloride, (R-(R*,R*))-Isomer
  • Propoxyphene Hydrochloride, (R-(R*,S*))-Isomer
  • Propoxyphene Hydrochloride, (S-(R*,R*))-Isomer
  • Propoxyphene Maleate, (+)-Isomer
  • Propoxyphene Phosphate, (S-(R*,S*))-Isomer
  • Propoxyphene Sulfate, (S-(R*,S*))-Isomer
  • Hydrochloride, Propoxyphene

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2008(1965); DEXTRO PROPOXYPHENE was heading 1963-1964

MeSH Hierarchy

Tree Number

  1. D02w.241w.081.751.120w

AMA Style

References

  1. National Library of Medicine. Dextropropoxyphene. Medical Subject Headings (MeSH). 2026. Unique ID D011431. http://id.nlm.nih.gov/mesh/2026/D011431
  2. Dextropropoxyphene. In: Wikipedia. https://en.wikipedia.org/wiki/Dextropropoxyphene
  3. Dextropropoxyphene. In: Wikidata. https://www.wikidata.org/wiki/Q2268608
  4. Dextropropoxyphene. In: PubChem Compound. CID 10100. https://pubchem.ncbi.nlm.nih.gov/compound/10100