Chemicals and Drugs

Dextromethorphan

Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.

Chemical Identity

Chemical Information

Molecular Formula
C18H25NO
Molecular Weight
271.4 g/mol
CAS Registry No.
125-71-3
IUPAC Name
(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene
InChIKey
MKXZASYAUGDDCJ-NJAFHUGGSA-N
SMILES
CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC
MeSH Unique ID
D003915
Source
PubChem CID 5360696

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • d-Methorphan
  • Delsym
  • Dextromethorphan Hydrobromide
  • Dextromethorphan Hydrobromide, (+-)-Isomer
  • Dextromethorphan Hydrobromide, Monohydrate
  • Dextromethorphan Hydrochloride
  • Dextromethorphan, (+-)-Isomer
  • Racemethorphan
  • Hydrobromide, Dextromethorphan
  • Hydrochloride, Dextromethorphan

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(72); was see under LEVORPHANOL 1972-90

MeSH Record

Previous Indexing

  • Antitussive Agents (1966-1971)
  • Morphinans (1969-1971)

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.577.249.200w
  2. D03w.605.497.212w
  3. D03w.633.400.686.212w
  4. D04w.615w.723w.795.200w

AMA Style

References

  1. National Library of Medicine. Dextromethorphan. Medical Subject Headings (MeSH). 2026. Unique ID D003915. http://id.nlm.nih.gov/mesh/2026/D003915
  2. Dextromethorphan. In: Wikipedia. https://en.wikipedia.org/wiki/Dextromethorphan
  3. Dextromethorphan. In: Wikidata. https://www.wikidata.org/wiki/Q407781
  4. Dextromethorphan. In: PubChem Compound. CID 5360696. https://pubchem.ncbi.nlm.nih.gov/compound/5360696