Structured Summary
Abstract
Minimal elements within a protein that are sufficient for recognition and degradation by a proteolytic apparatus. Inherent degrons are comprised of short linear amino acid sequences and secondary protein structural features that increase the affinity to E3 LIGASE; and are involved in regulating the specificity and timing of PROTEIN DEGRADATION. Acquired degrons are mostly transient and conferred by post-translational modifications of specific amino acids within proteins. (From Mol Cell. 2016 Sep 15;63(6):1055-65)
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Synonyms
28 entry terms
- Degron
- C-Degrons
- D-Box Motif
- Destruction Box
- Destruction Box Motif
- Destruction Boxes
- N-Degrons
- PEST Motif
- PEST Sequence
- Box Motif, Destruction
- Box Motifs, Destruction
- C Degrons
- C-Degron
- D Box Motif
- D-Box Motifs
- Destruction Box Motifs
- Motif, D-Box
- Motif, Destruction Box
- Motif, PEST
- Motifs, D-Box
- Motifs, Destruction Box
- Motifs, PEST
- N Degrons
- N-Degron
- PEST Motifs
- PEST Sequences
- Sequence, PEST
- Sequences, PEST
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Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
MeSH Record
History Note
2024
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AMA Style
References
- National Library of Medicine. Degrons. Medical Subject Headings (MeSH). 2026. Unique ID D000097791. http://id.nlm.nih.gov/mesh/2026/D000097791
- Degrons. In: Wikipedia. https://en.wikipedia.org/wiki/Degron
- Degrons. In: Wikidata. https://www.wikidata.org/wiki/Q5251856