Chemicals and Drugs

Debrisoquin

An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Chemical Identity

Chemical Information

Molecular Formula
C10H13N3
Molecular Weight
175.23 g/mol
CAS Registry No.
1131-64-2
IUPAC Name
3,4-dihydro-1H-isoquinoline-2-carboximidamide
InChIKey
JWPGJSVJDAJRLW-UHFFFAOYSA-N
SMILES
C1CN(CC2=CC=CC=C21)C(=N)N
MeSH Unique ID
D003647
Source
PubChem CID 2966

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • Debrisoquine
  • Tendor

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(73); was see under ISOQUINOLINES 1973-90

MeSH Record

Previous Indexing

  • Antihypertensive Agents (1966-1972)
  • Isoquinolines (1969-1972)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.531.205w

AMA Style

References

  1. National Library of Medicine. Debrisoquin. Medical Subject Headings (MeSH). 2026. Unique ID D003647. http://id.nlm.nih.gov/mesh/2026/D003647
  2. Debrisoquin. In: Wikipedia. https://en.wikipedia.org/wiki/Debrisoquine
  3. Debrisoquin. In: Wikidata. https://www.wikidata.org/wiki/Q3704421
  4. Debrisoquin. In: PubChem Compound. CID 2966. https://pubchem.ncbi.nlm.nih.gov/compound/2966