Phenomena and Processes

Death Effector Domain

A homotypic protein interaction module of the death domain superfamily that is composed of a bundle of six alpha-helices. The death effector domain shares sequence and structural similarities with the DEATH DOMAIN and CASPASE RECRUITMENT DOMAIN. It occurs in many proteins with essential functions in APOPTOSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A homotypic protein interaction module of the death domain superfamily that is composed of a bundle of six alpha-helices. The death effector domain shares sequence and structural similarities with the DEATH DOMAIN and CASPASE RECRUITMENT DOMAIN. It occurs in many proteins with essential functions in APOPTOSIS.

MeSH Record

Classification

Broader headings

Related Concepts

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See Also

MeSH Record

Synonyms

3 entry terms
  • DED Domain
  • DED Domains
  • Death Effector Domains

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Adaptor Proteins, Signal Transducing (1997-2016)
  • Amino Acid Sequence (1997-2016)
  • Death Domain Receptor Signaling Adaptor Proteins (2007-2016)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.750w.500.395.750w

AMA Style

References

  1. National Library of Medicine. Death Effector Domain. Medical Subject Headings (MeSH). 2026. Unique ID D000071461. http://id.nlm.nih.gov/mesh/2026/D000071461
  2. Death Effector Domain. In: Wikipedia. https://en.wikipedia.org/wiki/Death_effector_domain
  3. Death Effector Domain. In: Wikidata. https://www.wikidata.org/wiki/Q24781095