Chemicals and Drugs

Danazol

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.

Chemical Identity

Chemical Information

Molecular Formula
C22H27NO2
Molecular Weight
337.5 g/mol
CAS Registry No.
17230-88-5
IUPAC Name
(1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-ol
InChIKey
POZRVZJJTULAOH-LHZXLZLDSA-N
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC5=C(C[C@]34C)C=NO5
MeSH Unique ID
D003613
Source
PubChem CID 28417

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • Azol
  • Cyclomen
  • Danatrol
  • Danazant
  • Danazol-Ratiopharm
  • Danocrine
  • Danol
  • Danoval
  • Ladogal
  • Norciden
  • Panacrine
  • Danazol Ratiopharm

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under PREGNADIENES 1975-90

MeSH Record

Previous Indexing

  • Alkynes (1973-1974)
  • Hydroxysteroids (1973-1974)
  • Oxazoles (1973-1974)
  • Pregnadienes (1973-1974)

MeSH Hierarchy

Tree Number

  1. D04w.210.500w.745.432w.235w

AMA Style

References

  1. National Library of Medicine. Danazol. Medical Subject Headings (MeSH). 2026. Unique ID D003613. http://id.nlm.nih.gov/mesh/2026/D003613
  2. Danazol. In: Wikipedia. https://en.wikipedia.org/wiki/Danazol
  3. Danazol. In: Wikidata. https://www.wikidata.org/wiki/Q419652
  4. Danazol. In: PubChem Compound. CID 28417. https://pubchem.ncbi.nlm.nih.gov/compound/28417