Chemicals and Drugs

Dactinomycin

A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

Chemical Identity

Chemical Information

Molecular Formula
C62H86N12O16
Molecular Weight
1255.4 g/mol
CAS Registry No.
50-76-0
IUPAC Name
2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
InChIKey
RJURFGZVJUQBHK-IIXSONLDSA-N
SMILES
C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
MeSH Unique ID
D003609
Source
PubChem CID 457193

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Actinomycin D
  • Meractinomycin
  • Actinomycin
  • Cosmegen
  • Cosmegen Lyovac
  • Lyovac-Cosmegen
  • Lyovac Cosmegen
  • Lyovac, Cosmegen
  • LyovacCosmegen

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

66; ACTINOMYCIN was heading 1963-95

MeSH Hierarchy

Tree Numbers

  1. D03w.633.300.200w
  2. D04w.345w.566w.252w
  3. D12.644w.641w.252w

AMA Style

References

  1. National Library of Medicine. Dactinomycin. Medical Subject Headings (MeSH). 2026. Unique ID D003609. http://id.nlm.nih.gov/mesh/2026/D003609
  2. Dactinomycin. In: Wikipedia. https://en.wikipedia.org/wiki/Dactinomycin
  3. Dactinomycin. In: Wikidata. https://www.wikidata.org/wiki/Q186127
  4. Dactinomycin. In: PubChem Compound. CID 457193. https://pubchem.ncbi.nlm.nih.gov/compound/457193