Chemicals and Drugs

Dacarbazine

An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)

Chemical Identity

Chemical Information

Molecular Formula
C6H10N6O
Molecular Weight
182.18 g/mol
CAS Registry No.
4342-03-4
IUPAC Name
4-[(E)-dimethylaminodiazenyl]-1H-imidazole-5-carboxamide
InChIKey
FDKXTQMXEQVLRF-ZHACJKMWSA-N
SMILES
CN(C)/N=N/C1=C(NC=N1)C(=O)N
MeSH Unique ID
D003606
Source
PubChem CID 135398738

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

17 entry terms
  • 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
  • DIC
  • DTIC
  • Decarbazine
  • Dimethyl Imidazole Carboxamide
  • Dimethyl Triazeno Imidazole Carboxamide
  • ICDT
  • Carboxamide, Dimethyl Imidazole
  • Imidazole Carboxamide, Dimethyl
  • Biocarbazine
  • DTIC-Dome
  • Deticene
  • NSC-45388
  • DTIC Dome
  • DTICDome
  • NSC 45388
  • NSC45388

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

80(75)

MeSH Record

Previous Indexing

  • Amides (1966-1974)
  • Azo Compounds (1966-1972)
  • Imidazoles (1966-1974)
  • Triazenes (1972-1974)

MeSH Hierarchy

Tree Numbers

  1. D02w.925w.200w
  2. D03w.383.129w.308.240w

AMA Style

References

  1. National Library of Medicine. Dacarbazine. Medical Subject Headings (MeSH). 2026. Unique ID D003606. http://id.nlm.nih.gov/mesh/2026/D003606
  2. Dacarbazine. In: Wikipedia. https://en.wikipedia.org/wiki/Dacarbazine
  3. Dacarbazine. In: Wikidata. https://www.wikidata.org/wiki/Q416975
  4. Dacarbazine. In: PubChem Compound. CID 135398738. https://pubchem.ncbi.nlm.nih.gov/compound/135398738