Chemicals and Drugs

DNA Polymerase iota

A highly error-prone DNA polymerase. It is a member of the Y-family of DNA polymerases that are DNA DAMAGE tolerant and involved in TRANSLESION DNA SYNTHESIS. DNA polymerase iota is an orthologue of yeast Rad30. Its replication fidelity is template dependent and favors Hoogsteen base-pairing at its active site.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A highly error-prone DNA polymerase. It is a member of the Y-family of DNA polymerases that are DNA DAMAGE tolerant and involved in TRANSLESION DNA SYNTHESIS. DNA polymerase iota is an orthologue of yeast Rad30. Its replication fidelity is template dependent and favors Hoogsteen base-pairing at its active site.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

3 entry terms
  • POL iota
  • POLiota
  • RAD30B

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2023 (2000)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.696w.445w.308.300w.876.001

AMA Style

References

  1. National Library of Medicine. DNA Polymerase iota. Medical Subject Headings (MeSH). 2026. Unique ID D000094769. http://id.nlm.nih.gov/mesh/2026/D000094769
  2. DNA Polymerase iota. In: Wikidata. https://www.wikidata.org/wiki/Q21112143