Chemicals and Drugs

DNA Polymerase gamma

A DNA-directed DNA polymerase that functions in the replication of MITOCHONDRIAL DNA. Mutations in the gene that encodes this enzyme (POLG) are associated with some forms of OPHTHALMOPLEGIA, CHRONIC EXTERNAL PROGRESSIVE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A DNA-directed DNA polymerase that functions in the replication of MITOCHONDRIAL DNA. Mutations in the gene that encodes this enzyme (POLG) are associated with some forms of OPHTHALMOPLEGIA, CHRONIC EXTERNAL PROGRESSIVE.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

8 entry terms
  • DNA Polymerase Subunit gamma-1
  • Mitochondrial DNA Polymerase
  • PolG-alpha
  • DNA Polymerase Subunit gamma 1
  • DNA Polymerase, Mitochondrial
  • PolG alpha
  • Polymerase gamma, DNA
  • Polymerase, Mitochondrial DNA

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1997)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.445w.308.300w.169
  2. D12.776w.575.280

AMA Style

References

  1. National Library of Medicine. DNA Polymerase gamma. Medical Subject Headings (MeSH). 2026. Unique ID D000074002. http://id.nlm.nih.gov/mesh/2026/D000074002
  2. DNA Polymerase gamma. In: Wikidata. https://www.wikidata.org/wiki/Q21101133