Chemicals and Drugs

DNA Polymerase I

A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

6 entry terms
  • DNA Pol I
  • DNA Polymerase alpha
  • DNA-Dependent DNA Polymerase I
  • Klenow Fragment
  • DNA Dependent DNA Polymerase I
  • Polymerase alpha, DNA

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

84(77); for DNA POLYMERASE ALPHA use DNA POLYMERASE II 1982-97

MeSH Record

Previous Indexing

  • DNA Nucleotidyltransferases (1968-1976)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.696w.445w.308.300w.225w

AMA Style

References

  1. National Library of Medicine. DNA Polymerase I. Medical Subject Headings (MeSH). 2026. Unique ID D004256. http://id.nlm.nih.gov/mesh/2026/D004256
  2. DNA Polymerase I. In: Wikipedia. https://en.wikipedia.org/wiki/DNA_polymerase_I
  3. DNA Polymerase I. In: Wikidata. https://www.wikidata.org/wiki/Q2529148