Chemicals and Drugs

DNA-(Apurinic or Apyrimidinic Site) Lyase

A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

13 entry terms
  • AP Endonuclease
  • AP Lyase
  • Apurine-Apyrimidine Endonuclease
  • Apurinic DNA Endonuclease
  • Apurinic Endonuclease
  • DNA Lyase (Apurinic or Apyrimidinic)
  • Endodeoxyribonuclease (Apurinic or Apyrimidinic)
  • Apurine Apyrimidine Endonuclease
  • DNA Endonuclease, Apurinic
  • Endonuclease, AP
  • Endonuclease, Apurine-Apyrimidine
  • Endonuclease, Apurinic
  • Endonuclease, Apurinic DNA

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; use DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE (NM) 1980-2003

MeSH Record

Previous Indexing

  • Carbon-Oxygen Lyases (1978-2003)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.074.750w
  2. D08.811w.520w.241.225w

AMA Style

References

  1. National Library of Medicine. DNA-(Apurinic or Apyrimidinic Site) Lyase. Medical Subject Headings (MeSH). 2026. Unique ID D043603. http://id.nlm.nih.gov/mesh/2026/D043603
  2. DNA-(Apurinic or Apyrimidinic Site) Lyase. In: Wikipedia. https://en.wikipedia.org/wiki/DNA-(apurinic_or_apyrimidinic_site)_lyase
  3. DNA-(Apurinic or Apyrimidinic Site) Lyase. In: Wikidata. https://www.wikidata.org/wiki/Q5205676