Chemicals and Drugs

DEAD Box Protein 58

A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

5 entry terms
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
  • Probable ATP-Dependent RNA Helicase DDX58
  • RIG-I-like Receptor 1
  • Probable ATP Dependent RNA Helicase DDX58
  • RIG I like Receptor 1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • DEAD-box RNA Helicases (2006-2016)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.696w.445w.735.720w.249.750w

AMA Style

References

  1. National Library of Medicine. DEAD Box Protein 58. Medical Subject Headings (MeSH). 2026. Unique ID D000071457. http://id.nlm.nih.gov/mesh/2026/D000071457
  2. DEAD Box Protein 58. In: Wikipedia. https://en.wikipedia.org/wiki/RIG-I
  3. DEAD Box Protein 58. In: Wikidata. https://www.wikidata.org/wiki/Q21100537