Chemicals and Drugs

Cytokine TWEAK

A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

8 entry terms
  • Apo3 Ligand
  • TNF-Related Weak Inducer of Apoptosis
  • TWEAK Cytokine
  • Tumor Necrosis Factor Ligand Superfamily Member 12
  • Cytokine, TWEAK
  • Ligand, Apo3
  • TNF Related Weak Inducer of Apoptosis
  • TWEAK, Cytokine

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Tumor Necrosis Factors (2006-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.374w.750w.155
  2. D12.776w.467.374w.750w.155
  3. D23.529.374w.750w.155

AMA Style

References

  1. National Library of Medicine. Cytokine TWEAK. Medical Subject Headings (MeSH). 2026. Unique ID D000074049. http://id.nlm.nih.gov/mesh/2026/D000074049
  2. Cytokine TWEAK. In: Wikidata. https://www.wikidata.org/wiki/Q21135800