Chemicals and Drugs

Cytochrome-B(5) Reductase

A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

11 entry terms
  • NADH Cytochrome B5 Reductase
  • NADH-Cytochrome B5 Reductase
  • B5 Reductase, NADH-Cytochrome
  • Methemoglobin Reductase
  • NADH Methemoglobin Reductase
  • NADH-Ferrihemoglobin Reductase
  • Methemoglobin Reductase, NADH
  • NADH Ferrihemoglobin Reductase
  • Reductase, Methemoglobin
  • Reductase, NADH Methemoglobin
  • Reductase, NADH-Ferrihemoglobin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/defic: consider also METHEMOGLOBINEMIA

MeSH Record

History Note

2004; use CYTOCHROME B(5) REDUCTASE (NM) 1980-2003

MeSH Record

Previous Indexing

  • Cytochrome Reductases (1975-2003)
  • NADH, NADPH Oxidoreductases (1975-1990)
  • Oxidoreductases (1973-1974)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.682w.608.191.237w
  2. D12.776w.331w.186w

AMA Style

References

  1. National Library of Medicine. Cytochrome-B(5) Reductase. Medical Subject Headings (MeSH). 2026. Unique ID D042966. http://id.nlm.nih.gov/mesh/2026/D042966
  2. Cytochrome-B(5) Reductase. In: Wikipedia. https://en.wikipedia.org/wiki/Cytochrome_b5_reductase
  3. Cytochrome-B(5) Reductase. In: Wikidata. https://www.wikidata.org/wiki/Q418146