Chemicals and Drugs

Cyclic GMP-Dependent Protein Kinase Type I

A cyclic GMP-dependent protein kinase subtype that is expressed in SMOOTH MUSCLE tissues and plays a role in regulation of smooth muscle contraction. Two isoforms, PKGIalpha and PKGIbeta, of the type I protein kinase exist due to alternative splicing of its mRNA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cyclic GMP-dependent protein kinase subtype that is expressed in SMOOTH MUSCLE tissues and plays a role in regulation of smooth muscle contraction. Two isoforms, PKGIalpha and PKGIbeta, of the type I protein kinase exist due to alternative splicing of its mRNA.

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Classification

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MeSH Record

Synonyms

12 entry terms
  • cGMP-Dependent Protein Kinase I
  • Cyclic GMP Dependent Protein Kinase Type I
  • cGMP Dependent Protein Kinase I
  • PKGI beta
  • PKGIalpha
  • PKGIbeta
  • Protein Kinase G I alpha
  • cGK-Ialpha
  • cGMP-Dependent Protein Kinase Ialpha
  • cGMP-Dependent Protein Kinase Ibeta
  • cGMP Dependent Protein Kinase Ialpha
  • cGMP Dependent Protein Kinase Ibeta

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2013

MeSH Hierarchy

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AMA Style

References

  1. National Library of Medicine. Cyclic GMP-Dependent Protein Kinase Type I. Medical Subject Headings (MeSH). 2026. Unique ID D062965. http://id.nlm.nih.gov/mesh/2026/D062965
  2. Cyclic GMP-Dependent Protein Kinase Type I. In: Wikidata. https://www.wikidata.org/wiki/Q21106714