Diseases

Crush Syndrome

Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

3 entry terms
  • Crush Syndromes
  • Syndrome, Crush
  • Syndromes, Crush

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

91(75); was see under SHOCK, TRAUMATIC 1979-90; was see under KIDNEY FAILURE, ACUTE 1967-78; was see under ACUTE RENAL FAILURE 1963-66

MeSH Hierarchy

Tree Numbers

  1. C26w.257w.500w
  2. C26w.797.240w

AMA Style

References

  1. National Library of Medicine. Crush Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D003444. http://id.nlm.nih.gov/mesh/2026/D003444
  2. Crush Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Crush_syndrome
  3. Crush Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q1130527