Analytical, Diagnostic and Therapeutic Techniques, and Equipment

Cross-Over Studies

Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)

MeSH Record

Classification

Related Concepts

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MeSH Record

Synonyms

24 entry terms
  • Cross-Over Trials
  • Crossover Studies
  • Crossover Trials
  • Cross Over Studies
  • Cross Over Trials
  • Cross-Over Study
  • Crossover Study
  • Studies, Cross-Over
  • Studies, Crossover
  • Study, Cross-Over
  • Study, Crossover
  • Trial, Cross-Over
  • Trial, Crossover
  • Trials, Cross-Over
  • Trials, Crossover
  • Cross-Over Design
  • Crossover Design
  • Cross Over Design
  • Cross-Over Designs
  • Crossover Designs
  • Design, Cross-Over
  • Design, Crossover
  • Designs, Cross-Over
  • Designs, Crossover

MeSH Record

Indexing Annotation

IM general only; when pertinent add CLINICAL TRIAL (PT) or RANDOMIZED CONTROLLED TRIAL (PT)

MeSH Record

History Note

95

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Cross-Over Studies. Medical Subject Headings (MeSH). 2026. Unique ID D018592. http://id.nlm.nih.gov/mesh/2026/D018592
  2. Cross-Over Studies. In: Wikipedia. https://en.wikipedia.org/wiki/Crossover_study
  3. Cross-Over Studies. In: Wikidata. https://www.wikidata.org/wiki/Q1242899