Chemicals and Drugs

Cromakalim

A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)

Chemical Identity

Chemical Information

Molecular Formula
C16H18N2O3
Molecular Weight
286.33 g/mol
CAS Registry No.
94535-51-0
IUPAC Name
(3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile
InChIKey
TVZCRIROJQEVOT-LSDHHAIUSA-N
SMILES
CC1([C@@H]([C@H](C2=C(O1)C=CC(=C2)C#N)N3CCCC3=O)O)C
MeSH Unique ID
D019806
Source
PubChem CID 71191

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

14 entry terms
  • BRL-34915
  • BRL-38226
  • BRL-38227
  • Cromakalim, (3R-cis)-Isomer
  • Cromakalim, (3R-trans)-Isomer
  • Cromakalim, (3S-cis)-Isomer
  • Cromakalim, (3S-trans)-Isomer
  • Cromakalim, (trans)-Isomer
  • Lemakalim
  • Levcromakalim
  • BRL 38226
  • BRL 38227
  • BRL38226
  • BRL38227

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

98; use CROMAKALIM (NM) 1986-97

MeSH Record

Previous Indexing

  • Benzopyrans (1986-1997)
  • Pyrroles (1986-1997)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.129w.578.150w
  2. D03w.383.663.283.455w
  3. D03w.633.100.150.455w

AMA Style

References

  1. National Library of Medicine. Cromakalim. Medical Subject Headings (MeSH). 2026. Unique ID D019806. http://id.nlm.nih.gov/mesh/2026/D019806
  2. Cromakalim. In: Wikipedia. https://en.wikipedia.org/wiki/Cromakalim
  3. Cromakalim. In: Wikidata. https://www.wikidata.org/wiki/Q3698301
  4. Cromakalim. In: PubChem Compound. CID 71191. https://pubchem.ncbi.nlm.nih.gov/compound/71191