Structured Summary
Abstract
A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER.
Chemical Identity
Chemical Information
- Molecular Formula
- C21H22Cl2FN5O
- Molecular Weight
- 450.3 g/mol
- CAS Registry No.
- 877399-52-5
- IUPAC Name
- 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
- InChIKey
- KTEIFNKAUNYNJU-GFCCVEGCSA-N
- SMILES
- C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
- MeSH Unique ID
- D000077547
- Source
- PubChem CID 11626560
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
7 entry terms
- PF 02341066
- PF-02341066
- PF-2341066
- PF02341066
- Xalkori
- PF 2341066
- PF2341066
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (2010)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Crizotinib. Medical Subject Headings (MeSH). 2026. Unique ID D000077547. http://id.nlm.nih.gov/mesh/2026/D000077547
- Crizotinib. In: Wikipedia. https://en.wikipedia.org/wiki/Crizotinib
- Crizotinib. In: Wikidata. https://www.wikidata.org/wiki/Q5186964
- Crizotinib. In: PubChem Compound. CID 11626560. https://pubchem.ncbi.nlm.nih.gov/compound/11626560