Chemicals and Drugs

Corticotropin-Releasing Hormone

A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

14 entry terms
  • ACTH-Releasing Factor
  • ACTH-Releasing Hormone
  • CRF (ACTH)
  • CRF-41
  • Corticoliberin
  • Corticotropin-Releasing Factor
  • Corticotropin-Releasing Factor-41
  • Corticotropin-Releasing Hormone-41
  • ACTH Releasing Factor
  • ACTH Releasing Hormone
  • Corticotropin Releasing Factor
  • Corticotropin Releasing Factor 41
  • Corticotropin Releasing Hormone
  • Corticotropin Releasing Hormone 41

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

90; was CORTICOTROPIN RELEASING HORMONE 1974-89; was CORTICOTROPIN RELEASING FACTOR 1968-73

MeSH Record

Previous Indexing

  • Adrenocorticotropic Hormone (1966-1967)
  • Hypothalamo-Hypophyseal System/physiology (1966-1967)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.327.740.140w
  2. D12.644w.400w.400.740.140w
  3. D12.644w.548w.365.740.140w
  4. D12.776w.631w.650w.405.740.140w

MeSH Record

NLM Classification

WK 515

AMA Style

References

  1. National Library of Medicine. Corticotropin-Releasing Hormone. Medical Subject Headings (MeSH). 2026. Unique ID D003346. http://id.nlm.nih.gov/mesh/2026/D003346
  2. Corticotropin-Releasing Hormone. In: Wikipedia. https://en.wikipedia.org/wiki/Corticotropin-releasing_hormone
  3. Corticotropin-Releasing Hormone. In: Wikidata. https://www.wikidata.org/wiki/Q386664