Structured Summary
Abstract
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
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Classification
Broader headings
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MeSH Record
Synonyms
15 entry terms
- Acute Myeloid Leukemia 1 Protein
- Core-Binding Factor Alpha 2 Protein
- Pebp2a2 Protein
- Runt-Related Transcription Factor 1
- Runx1 Protein
- Core Binding Factor Alpha 2 Protein
- Runt Related Transcription Factor 1
- AML1A Protein
- AML1B Protein
- AML1C Protein
- AML1D Protein
- Acute Myeloid Leukemia 1A Protein
- Acute Myeloid Leukemia 1B Protein
- Acute Myeloid Leukemia 1C Protein
- Acute Myeloid Leukemia 1D Protein
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006(1993)
MeSH Record
Previous Indexing
- DNA-Binding Proteins (1996-2005)
- Neoplasm Proteins (1993-1996)
- Proto-Oncogene Proteins (1996-2005)
- Transcription Factors (1996-2005)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Core Binding Factor Alpha 2 Subunit. Medical Subject Headings (MeSH). 2026. Unique ID D050676. http://id.nlm.nih.gov/mesh/2026/D050676
- Core Binding Factor Alpha 2 Subunit. In: Wikidata. https://www.wikidata.org/wiki/Q4392325