Structured Summary
Abstract
P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.
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Broader headings
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MeSH Record
Synonyms
35 entry terms
- Copper-Transporting ATPase
- Copper-Transporting Adenosine Triphosphatases
- Cu(+)-Transporting ATPases
- Cu-Transporting ATPases
- ATPase, Copper-Transporting
- ATPases, Copper-Transporting
- ATPases, Cu-Transporting
- Adenosine Triphosphatases, Copper-Transporting
- Copper Transporting ATPase
- Copper Transporting ATPases
- Copper Transporting Adenosine Triphosphatases
- Cu Transporting ATPases
- Triphosphatases, Copper-Transporting Adenosine
- ATP7A Protein
- ATP7B Cu-Binding P Type ATPase
- ATPase Copper Transporting alpha
- ATPase, Cu++ Transporting, beta Polypeptide (Wilson Disease)
- Copper Pump 1
- Copper-Transporting ATPase 1
- Copper-Transporting ATPase 2
- Menkes Disease-Associated Protein
- PINA Enzyme
- Pineal Night-Specific ATPase
- Wilson Disease Cu-Binding P Type ATPase
- Wilson Disease Protein
- ATP7B Cu Binding P Type ATPase
- ATPase 1, Copper-Transporting
- ATPase 2, Copper-Transporting
- ATPase, Pineal Night-Specific
- Copper Transporting ATPase 1
- Copper Transporting ATPase 2
- Menkes Disease Associated Protein
- Night-Specific ATPase, Pineal
- Pineal Night Specific ATPase
- Wilson Disease Cu Binding P Type ATPase
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018 (1994)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Copper-Transporting ATPases. Medical Subject Headings (MeSH). 2026. Unique ID D000073840. http://id.nlm.nih.gov/mesh/2026/D000073840
- Copper-Transporting ATPases. In: Wikidata. https://www.wikidata.org/wiki/Q108236356