Diseases

Congenital Pain Insensitivity

A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

11 entry terms
  • Analgesia, Congenital
  • Channelopathy-Associated Insensitivity To Pain
  • Congenital Analgesia
  • Congenital Indifference to Pain
  • Congenital Insensitivity To Pain
  • Congenital Pain Indifference
  • Insensitivity To Pain, Congenital
  • Insensitivity, Congenital Pain
  • Pain Indifference, Congenital
  • Pain Insensitivity, Congenital
  • Congenital Pain Indifferences

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

congenital insensitivity to pain with anhidrosis = HSAN TYPE IV see NEUROPATHIES, HEREDITARY SENSORY AND AUTONOMIC

MeSH Record

History Note

96; was ANALGESIA, CONGENITAL 1964-95 (Prov 1964-72); PAIN INSENSITIVITY, CONGENITAL was see ANALGESIA, CONGENITAL 1973-95

MeSH Hierarchy

Tree Numbers

  1. C10w.668w.829w.700w
  2. C16w.320w.775w

AMA Style

References

  1. National Library of Medicine. Congenital Pain Insensitivity. Medical Subject Headings (MeSH). 2026. Unique ID D000699. http://id.nlm.nih.gov/mesh/2026/D000699
  2. Congenital Pain Insensitivity. In: Wikipedia. https://en.wikipedia.org/wiki/Congenital_insensitivity_to_pain
  3. Congenital Pain Insensitivity. In: Wikidata. https://www.wikidata.org/wiki/Q3045238