Structured Summary
Abstract
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the membrane attack complex or MAC.
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Classification
Broader headings
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Drug Class
Pharmacological Action
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See Also
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Synonyms
11 entry terms
- C 5b-9
- C5b-8-poly-C9
- C5b-9
- Complement Complex C5b-9
- Cytolytic Terminal Complement Complex
- Membrane Attack Complex
- Terminal Complement Complex
- C5b 8 poly C9
- Complement Complex C5b 9
- Complement Complex, Terminal
- Complex, Terminal Complement
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
90
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Previous Indexing
- Complement (1973-1989)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Complement Membrane Attack Complex. Medical Subject Headings (MeSH). 2026. Unique ID D015938. http://id.nlm.nih.gov/mesh/2026/D015938
- Complement Membrane Attack Complex. In: Wikipedia. https://en.wikipedia.org/wiki/Complement_membrane_attack_complex
- Complement Membrane Attack Complex. In: Wikidata. https://www.wikidata.org/wiki/Q1919945