Structured Summary
Abstract
A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.
MeSH Record
Classification
Broader headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
6 entry terms
- C9 Complement
- Complement 9
- Complement Component 9
- C9, Complement
- Complement, C9
- Component 9, Complement
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006 (1975)
MeSH Record
Previous Indexing
- Bacteriolysis (1966-1974)
- Complement (1968-1974)
- Hemolysis (1966-1974)
- specific cell
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Complement C9. Medical Subject Headings (MeSH). 2026. Unique ID D003186. http://id.nlm.nih.gov/mesh/2026/D003186
- Complement C9. In: Wikipedia. https://en.wikipedia.org/wiki/Complement_component_9
- Complement C9. In: Wikidata. https://www.wikidata.org/wiki/Q21102471