Chemicals and Drugs

Complement C4b

The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • C4b Complement
  • Complement 4b
  • Complement Component 4b
  • C4b, Complement
  • Complement, C4b
  • Component 4b, Complement

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006 (1990)

MeSH Record

Previous Indexing

  • Complement 4 (1975-1989)

MeSH Hierarchy

Tree Number

  1. D12.776w.124w.486.274.350w.260

AMA Style

References

  1. National Library of Medicine. Complement C4b. Medical Subject Headings (MeSH). 2026. Unique ID D015935. http://id.nlm.nih.gov/mesh/2026/D015935
  2. Complement C4b. In: Wikidata. https://www.wikidata.org/wiki/Q21102479