Chemicals and Drugs

Coagulase

Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Clumping Factor (Staphylococcal)
  • Staphylocoagulase
  • Staphylococcal Clumping Factor
  • Staphylococcus aureus clone pSCa2 of Coagulase
  • Staphylococcus aureus strain 213 of Coagulase
  • Staphylococcus aureus strain 8325-4 of Coagulase
  • Clumping Factor, Staphylococcal
  • Factor, Staphylococcal Clumping
  • Staphylococcus aureus strain 8325 4 of Coagulase

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

do not routinely add when indexing coagulase negative organisms; index only when discussed

MeSH Record

History Note

66(64); was see under HYDROLASES 1963-65; STAPHYLOCOAGULASE was see under HYDROLASES 1963-67

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.300w.174w
  2. D12.776w.097.181w

AMA Style

References

  1. National Library of Medicine. Coagulase. Medical Subject Headings (MeSH). 2026. Unique ID D003030. http://id.nlm.nih.gov/mesh/2026/D003030
  2. Coagulase. In: Wikipedia. https://en.wikipedia.org/wiki/Coagulase
  3. Coagulase. In: Wikidata. https://www.wikidata.org/wiki/Q1755077