Chemicals and Drugs

Clozapine

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Chemical Identity

Chemical Information

Molecular Formula
C18H19ClN4
Molecular Weight
326.8 g/mol
CAS Registry No.
5786-21-0
IUPAC Name
3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
InChIKey
QZUDBNBUXVUHMW-UHFFFAOYSA-N
SMILES
CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
MeSH Unique ID
D003024
Source
PubChem CID 135398737

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • Clozaril
  • Leponex

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under DIBENZAZEPINES 1975-90

MeSH Record

Previous Indexing

  • Dibenzazepines (1971-1974)
  • Piperazines (1971-1974)

MeSH Hierarchy

Tree Number

  1. D03w.633.300.240.220w

AMA Style

References

  1. National Library of Medicine. Clozapine. Medical Subject Headings (MeSH). 2026. Unique ID D003024. http://id.nlm.nih.gov/mesh/2026/D003024
  2. Clozapine. In: Wikipedia. https://en.wikipedia.org/wiki/Clozapine
  3. Clozapine. In: Wikidata. https://www.wikidata.org/wiki/Q221361
  4. Clozapine. In: PubChem Compound. CID 135398737. https://pubchem.ncbi.nlm.nih.gov/compound/135398737